UCL Discovery 1470296 RQR8 A universal safety switch for cellular therapies By epitope mapping we identified a 16 amino acid linear fragment of CD34 which demonstrates approximately equivalent binding of QBEnd10 as the native antigen Next we Author BM Philip Publish Year 2015 Event University College London Type Thesis Doctoral
National Center for Biotechnology Information pmc articles Targeted multi epitope switching enables straightforward RQR8 in particular is an immunological safety switch composed of QBEnd10 a CD34 epitope that can be used for positive selection during manufacturing two CD20 mimotopes Author Laura Mosti Lukas M Langner Kay O Chmielewski Patrick Arbuthnot Jamal Alzubi Toni Cathomen Publish Year 2021 DOI 10 1038 s41434 021 00220 6 Publication Gene Ther 2021 28 9 602 612
PubMed 33526841 Targeted multi epitope switching enables straightforward To address these limitations we integrated RQR8 a multi epitope molecule harboring a CD34 epitope and two CD20 mimotopes alongside a CD19 targeting CAR into the CD52
Cell Press molecular therapy family molecular therapy 86 A Highly Compact Epitope Based Marker Suicide Gene for After much optimisation we determined that a construct designated RQR8 composed of two Rituximab binding epitopes flanking a single QBEnd10 epitope on the CD8 stalk
Rqr8 Cd34
Nature articles s41434 021 00220 6 Targeted multi epitope switching enables straightforward Feb 1 2021 To address these limitations we integrated RQR8 a multi epitope molecule harboring a CD34 epitope and two CD20 mimotopes alongside a CD19 targeting CAR into the CD52 Author Laura Mosti Lukas M Langner Kay O Chmielewski Patrick Arbuthnot Jamal Alzubi Toni Cathomen Publish Year 2021
Springer article 10 Functional Validation of the RQR8 Suicide Marker Gene in Apr 22 2023 RQR8 is a gene that integrates CD34 and CD20 epitopes In our study we incorporated the suicide gene RQR8 into CAR T cells so it enabled rituximab to eliminate Author Xia Xiong
ResearchGate publication 319538436 RQR8 A RQR8 A universal safety switch for cellular therapies Aug 28 2015 Following optimisation we established a 136 amino acid construct designated RQR8 composed of two rituximab binding epitopes flanking the QBEnd10 epitope on a CD8 stalk People also search for
PubMed 24970931 A highly compact epitope based marker suicide gene for easier Aug 21 2014 We have created a highly compact marker suicide gene for T cells combining target epitopes from both CD34 and CD20 antigens RQR8 This construct allows selection with
Rqr8 Cd34
American Society of Hematology blood article A highly compact epitope based marker suicide gene for easier Aug 21 2014 We have created a highly compact marker suicide gene for T cells combining target epitopes from both CD34 and CD20 antigens RQR8 This construct allows selection with Author Brian Philip Evangelia Kokalaki Leila Mekkaoui Simon Thomas Karin Straathof Barry Flutter Virn Publish Year 2014
Semantic Scholar paper RQR8 A universal safety RQR8 A universal safety switch for cellular therapies Aug 28 2015 Following optimisation we established a 136 amino acid construct designated RQR8 composed of two rituximab binding epitopes flanking the QBEnd10 epitope on a CD8 stalk